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Arch Oral Biol. 2017 Nov;83:7-12. doi: 10.1016/j.archoralbio.2017.06.021. Epub 2017 Jul 1.

Optimizing concentration of titanium tetrafluoride solution for human dentine remineralization.

Author information

1
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, China; Department of Preventive Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, China.
2
Department of Preventive Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, China.
3
Department of Stomatology, Xi'an Medical University, Xi'an, China.
4
Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, CSA142, Health Sciences Campus, University of Southern California, Los Angeles, CA, USA.
5
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, China; Department of Preventive Dentistry, College of Stomatology, Xi'an Jiaotong University, Xi'an, China; Clinical Research Center of Shaanxi Province for Dental and Maxillofacial Diseases, College of Stomatology, Xi'an Jiaotong University, China. Electronic address: ruanjp@xjtu.edu.cn.

Abstract

OBJECTIVE:

The aim of the present study was to select the optimal concentration of TiF4 solution to facilitate the remineralization of early dentine caries lesions.

DESIGN:

Sixty human dentine specimens were cut and randomly divided into 6 groups (1%, 2%, 3%, 4% TiF4 groups, 2.712% NaF group and distilled deionized water (DDW) control group). Artificial dentine caries-like lesions were created. After being subjected to fluoride treatment and immersed in remineralizing solution for 2weeks, the specimens were observed by microCT, scanning electron microscopy (SEM) and X-ray photoelectron spectroscopy (XPS). Data were analysed using linear regression analysis (P<0.05).

RESULTS:

The lesion depths of the specimens treated by 2% TiF4 solution were statistically less than those of the other groups. Further, the greyscale values of these lesion areas were greater. The 3% and 4% TiF4 solutions caused further lesion demineralization. The 2.712% NaF solution seemed to be detrimental to remineralization during the experimental time, as the subsurface area remained hypomineralized with a thick precipitation layer on the surface.

CONCLUSIONS:

The 2% TiF4 solution demonstrated better remineralizing potency than did the other treatments.

KEYWORDS:

Dentine; Remineralization; Titanium tetrafluoride

[Indexed for MEDLINE]

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