Format

Send to

Choose Destination
See comment in PubMed Commons below
Rev Port Cardiol. 2017 Jul - Aug;36(7-8):499-508. doi: 10.1016/j.repc.2016.10.013. Epub 2017 Jul 4.

The relationship between erythrocyte membrane fatty acid levels and cardiac autonomic function in obese children.

[Article in English, Portuguese]

Author information

1
Gulhane Education and Research Hospital, Department of Pediatric Cardiology, Ankara, Turkey. Electronic address: mustafagulgun@yahoo.com.
2
Gulhane Education and Research Hospital, Department of Pediatric Cardiology, Ankara, Turkey.
3
Gulhane Education and Research Hospital, Department of Biochemistry, Ankara, Turkey.
4
Dr. Zekai Tahir Burak Woman's Health Education and Research Hospital, Department of Pediatrics, Ankara, Turkey.
5
Gulhane Military Medical Academy, Department of Pediatric Endocrinology, Ankara, Turkey.
6
Gulhane Education and Research Hospital, Department of Epidemiology, Ankara, Turkey.

Abstract

OBJECTIVE:

Childhood obesity is a worldwide health concern. Studies have shown autonomic dysfunction in obese children. The exact mechanism of this dysfunction is still unknown. The aim of this study was to assess the relationship between erythrocyte membrane fatty acid (EMFA) levels and cardiac autonomic function in obese children using heart rate variability (HRV).

METHODS:

A total of 48 obese and 32 healthy children were included in this case-control study. Anthropometric and biochemical data, HRV indices, and EMFA levels in both groups were compared statistically.

RESULTS:

HRV parameters including standard deviation of normal-to-normal R-R intervals (NN), root mean square of successive differences, the number of pairs of successive NNs that differ by >50 ms (NN50), the proportion of NN50 divided by the total number of NNs, high-frequency power, and low-frequency power were lower in obese children compared to controls, implying parasympathetic impairment. Eicosapentaenoic acid and docosahexaenoic acid levels were lower in the obese group (p<0.001 and p=0.012, respectively). In correlation analysis, in the obese group, body mass index standard deviation and linoleic acid, arachidonic acid, triglycerides, and high-density lipoprotein levels showed a linear correlation with one or more HRV parameter, and age, eicosapentaenoic acid, and systolic and diastolic blood pressure correlated with mean heart rate. In linear regression analysis, age, dihomo-gamma-linolenic acid, linoleic acid, arachidonic acid, body mass index standard deviation, systolic blood pressure, triglycerides, low-density lipoprotein and high-density lipoprotein were related to HRV parameters, implying an effect on cardiac autonomic function.

CONCLUSION:

There is impairment of cardiac autonomic function in obese children. It appears that levels of EMFAs such as linoleic acid, arachidonic acid and dihomo-gamma-linolenic acid play a role in the regulation of cardiac autonomic function in obese children.

KEYWORDS:

Child; Criança; Fatty acid; Frequência cardíaca; Heart rate; Obesidade; Obesity; Omega-3 fatty acids; Ácidos gordos; Ácidos gordos ómega 3

PMID:
28687367
DOI:
10.1016/j.repc.2016.10.013
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Ediciones Doyma, S.L.
    Loading ...
    Support Center