Format

Send to

Choose Destination
PLoS One. 2017 Jul 7;12(7):e0180365. doi: 10.1371/journal.pone.0180365. eCollection 2017.

Coronary artery disease-associated genetic variants and biomarkers of inflammation.

Author information

1
Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
2
Faculty of Health, Institute of Clinical Medicine, Aarhus University, Aarhus, Denmark.
3
Department of Biomedicine, Aarhus University, Aarhus, Denmark.
4
Leeds Institute for Cardiovascular and Metabolic Medicine (LICAMM), University of Leeds, Leeds, United Kingdom.
5
Department of Clinical Biochemistry, Aarhus University Hospital, Aarhus, Denmark.

Abstract

INTRODUCTION:

Genetic constitution and inflammation both contribute to development of coronary artery disease (CAD). Several CAD-associated single-nucleotide polymorphisms (SNPs) have recently been identified, but their functions are largely unknown. We investigated the associations between CAD-associated SNPs and five CAD-related inflammatory biomarkers.

METHODS:

We genotyped 45 CAD-associated SNPs in 701 stable CAD patients in whom levels of high-sensitivity C-reactive protein (hsRCP), interleukin-6, calprotectin, fibrinogen and complement component 3 levels had previously been measured. A genetic risk score was calculated to assess the combined risk associated with all the genetic variants. A multiple linear regression model was used to assess associations between the genetic risk score, single SNPs, and the five inflammatory biomarkers.

RESULTS:

The minor allele (G) (CAD risk allele) of rs2075650 (TOMM40/APOE) was associated with lower levels of high-sensitivity C-reactive protein (effect per risk allele: -0.37 mg/l [95%CI -0.56 to -0.18 mg/l]). The inflammatory markers tested showed no association with the remaining 44 SNPs or with the genetic risk score.

CONCLUSIONS:

In stable CAD patients, the risk allele of a common CAD-associated marker at the TOMM40/APOE locus was associated with lower hsCRP levels. No other genetic variants or the combined effect of all variants were associated with the five inflammatory biomarkers.

PMID:
28686695
PMCID:
PMC5501546
DOI:
10.1371/journal.pone.0180365
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Public Library of Science Icon for PubMed Central
Loading ...
Support Center