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J Med Food. 2017 Sep;20(9):855-863. doi: 10.1089/jmf.2017.3966. Epub 2017 Jul 7.

γ-Oryzanol-Rich Black Rice Bran Extract Enhances the Innate Immune Response.

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1 Department of Biological Sciences, Sanghuh College of Life Sciences, Konkuk University , Seoul, Korea.
2 Cancer and Metabolism Institute, Konkuk University , Seoul, Korea.
3 Functional Food and Nutrition Division, National Institute of Agricultural Sciences , Rural Development Administration, Jeonju, Korea.
4 Division of Bioscience and Biotechnology, BMIC, Konkuk University , Seoul, Korea.


The innate immune response is an important host primary defense system against pathogens. γ-Oryzanol is one of the nutritionally important phytoceutical components in rice bran oil. The goal of this study was to investigate the effect of γ-oryzanol-rich extract from black rice bran (γORE) on the activation of the innate immune system. In this study, we show that γORE increased the expression of CD14 and Toll-like receptor 4 and enhanced the phagocytic activity of RAW264.7 macrophages. Furthermore, γORE and its active ingredient γ-oryzanol promoted the secretion of innate cytokines, interleukin-8, and CCL2, which facilitate phagocytosis by RAW264.7 cells. These findings suggest that γ-oryzanol in the γORE enhances innate immune responses.


black rice bran; innate cytokine; innate immune response; phagocytosis; toll-like receptor 4; γ-oryzanol

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