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J Am Heart Assoc. 2017 Jul 6;6(7). pii: e005025. doi: 10.1161/JAHA.116.005025.

Cytomegalovirus Infection and Relative Risk of Cardiovascular Disease (Ischemic Heart Disease, Stroke, and Cardiovascular Death): A Meta-Analysis of Prospective Studies Up to 2016.

Author information

1
Department of Cardiology Ward 2, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China washingtonhr@163.com dongliang003@live.cn.
2
Department of Cardiology Ward 2, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China.
3
Department of Endocrinology and Diabetes, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China.
4
Department of Joint Surgery, Luohe Central Hospital, The First Affiliated Hospital of Luohe Medical College, Luohe, China.
5
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

Abstract

BACKGROUND:

Several studies have suggested that cytomegalovirus infection is likely associated with an increased relative risk of cardiovascular disease (CVD); however, the results are inconsistent. We aimed to provide a systematic review and meta-analysis of community-based prospective studies assessing the association between cytomegalovirus infection and relative risk of CVD.

METHODS AND RESULTS:

We searched Medline and EMBASE to retrieve prospective studies that reported risk estimates of the association between cytomegalovirus infection and relative risk of CVD. The search yielded 10 articles including a total of 34 564 participants and 4789 CVD patients. Overall, exposure to cytomegalovirus infection was associated with a 22% (relative risk: 1.22, 95% CI: 1.07-1.38, P=0.002) increased relative risk of future CVD. We estimated that 13.4% of CVD incidence could be attributable to cytomegalovirus infection.

CONCLUSIONS:

In conclusion, cytomegalovirus infection is associated with a significantly increased relative risk of CVD.

KEYWORDS:

cardiovascular disease risk factors; cytomegalovirus; infectious disease; meta‐analysis; prospective cohort study; virus

PMID:
28684641
PMCID:
PMC5586265
DOI:
10.1161/JAHA.116.005025
[Indexed for MEDLINE]
Free PMC Article

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