Format

Send to

Choose Destination
Am J Physiol Gastrointest Liver Physiol. 2017 Oct 1;313(4):G285-G299. doi: 10.1152/ajpgi.00073.2017. Epub 2017 Jul 6.

Dclk1-expressing tuft cells: critical modulators of the intestinal niche?

Author information

1
Division of Digestive and Liver Diseases, Department of Medicine, Columbia University Medical Center, New York, New York.
2
II. Medizinische Klinik, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
3
Medizinische Klinik und Poliklinik III, Klinikum der Universität München, Munich, Germany.
4
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
5
Department of Genetics and Development, Columbia University Medical Center, New York, New York; and.
6
Department of Pathology and Cell Biology, Columbia University Medical Center, New York, New York.
7
II. Medizinische Klinik, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; michael.quante@tum.de.

Abstract

Dclk1-expressing tuft cells constitute a unique intestinal epithelial lineage that is distinct from enterocytes, Paneth cells, goblet cells, and enteroendocrine cells. Tuft cells express taste-related receptors and distinct transcription factors and interact closely with the enteric nervous system, suggesting a chemosensory cell lineage. In addition, recent work has shown that tuft cells interact closely with cells of the immune system, with a critical role in the cellular regulatory network governing responses to luminal parasites. Importantly, ablation of tuft cells severely impairs epithelial proliferation and tissue regeneration after injury, implicating tuft cells in the modulation of epithelial stem/progenitor function. Finally, tuft cells expand during chronic inflammation and in preneoplastic tissues, suggesting a possible early role in inflammation-associated tumorigenesis. Hence, we outline and discuss emerging evidence that strongly supports tuft cells as key regulatory cells in the complex network of the intestinal microenvironment.

KEYWORDS:

cancer initiation; inflammation; intestinal stem cells; niche cell; tuft cell

PMID:
28684459
PMCID:
PMC5668570
DOI:
10.1152/ajpgi.00073.2017
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Atypon Icon for PubMed Central
Loading ...
Support Center