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Rev Gastroenterol Mex. 2018 Jan - Mar;83(1):41-50. doi: 10.1016/j.rgmx.2017.03.004. Epub 2017 Jul 3.

Present and past perspectives on Clostridium difficile infection.

[Article in English, Spanish]

Author information

1
Coordinación de Servicios Médicos, Cruz Roja Mexicana I.A.P., Delegación Huixquilucan, Huixquilucan, Estado de México, México. Electronic address: diego.alvarez.hernandez@hotmail.com.
2
Departamento de Cirugía General, Hospital Español de México, Ciudad de México, México.
3
Departamento de Cirugía General, Fundación Clínica Médica Sur, Ciudad de México, México.
4
Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Naucalpan de Juárez, Estado de México, México.
5
Departamento de Microbiología y Parasitología, Facultad de Ciencias de la Salud, Universidad Anáhuac México Norte, Naucalpan de Juárez, Estado de México, México.

Abstract

Clostridium difficile is a Gram-positive bacillus that has become one of the main hospital-acquired human gastrointestinal infections in recent years. Its incidence is on the rise, involving more virulent strains, affecting new and previously uncontemplated groups of patients, and producing changes in clinical presentation and treatment response that influence disease outcome. Early diagnosis and disease stratification based on the severity of C.difficile infection are essential for therapeutic management and the implementation of containment measures. However, the speed at which new strains with greater pathogenicity are developing is surpassing that of the development of new drugs, making it necessary to validate other therapeutic options. The present article is a review of the epidemiologic, pathophysiologic, diagnostic, and therapeutic aspects of C.difficile infection, from its first isolation to the present date, that aims to contribute to the preparation of general physicians and specialists, so that patients with this infection receive opportune and quality medical attention.

KEYWORDS:

Clostridium difficile; Colitis pseudomembranosa; Megacolon tóxico; Pseudomembranous colitis; Toxic megacolon

PMID:
28684034
DOI:
10.1016/j.rgmx.2017.03.004
[Indexed for MEDLINE]
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