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Cardiovasc Diabetol. 2017 Jul 6;16(1):85. doi: 10.1186/s12933-017-0570-2.

Reduced HDL function in children and young adults with type 1 diabetes.

Author information

1
Children's Hospital Oakland Research Institute, Oakland, CA, USA. martin.heier@medisin.uio.no.
2
Faculty of Medicine, University of Oslo, Oslo, Norway. martin.heier@medisin.uio.no.
3
Children's Hospital Oakland Research Institute, Oakland, CA, USA.
4
Oslo Centre for Biostatistics and Epidemiology, Research Support Services, Oslo University Hospital, Oslo, Norway.
5
Faculty of Medicine, University of Oslo, Oslo, Norway.
6
Center for Clinical Heart Research and Department of Cardiology, Oslo University Hospital, Oslo, Norway.
7
Department of Pediatric and Adolescent Medicine, Akershus University Hospital, Lørenskog, Norway.
8
Department of Endocrinology, Oslo University Hospital, Oslo, Norway.
9
Pediatric Department, Oslo University Hospital, Oslo, Norway.

Abstract

BACKGROUND:

Patients with type 1 diabetes (T1D) are at increased risk of cardiovascular disease (CVD). Measures of high-density lipoprotein (HDL) function provide a better risk estimate for future CVD events than serum levels of HDL cholesterol. The objective of this study was to evaluate HDL function in T1D patients shortly after disease onset compared with healthy control subjects.

METHODS:

Participants in the atherosclerosis and childhood diabetes study were examined at baseline and after 5 years. At baseline, the cohort included 293 T1D patients with a mean age of 13.7 years and mean HbA1c of 8.4%, along with 111 healthy control subjects. Their HDL function, quantified by HDL-apoA-I exchange (HAE), was assessed at both time points. HAE is a measure of HDL's dynamic property, specifically its ability to release lipid-poor apolipoprotein A-I (apoA-I), an essential step in reverse cholesterol transport.

RESULTS:

The HAE-apoA-I ratio, reflecting the HDL function per concentration unit apoA-I, was significantly lower in the diabetes group both at baseline, 0.33 (SD = 0.06) versus 0.36 (SD = 0.06) %HAE/mg/dL, p < 0.001 and at follow-up, 0.34 (SD = 0.06) versus 0.36 (SD = 0.06)  %HAE/mg/dL, p = 0.003. HAE-apoA-I ratio was significantly and inversely correlated with HbA1c in the diabetes group. Over the 5 years of the study, the mean HAE-apoA-I ratio remained consistent in both groups. Individual changes were less than 15% for half of the study participants.

CONCLUSIONS:

This study shows reduced HDL function, quantified as HAE-apoA-I ratio, in children and young adults with T1D compared with healthy control subjects. The differences in HDL function appeared shortly after disease onset and persisted over time.

KEYWORDS:

Atherosclerosis; HDL function; HDL-apoA-I exchange; High-density lipoprotein; Type 1 diabetes

PMID:
28683835
PMCID:
PMC5501001
DOI:
10.1186/s12933-017-0570-2
[Indexed for MEDLINE]
Free PMC Article

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