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Curr Opin Virol. 2017 Jun;24:132-139. doi: 10.1016/j.coviro.2017.06.009. Epub 2017 Jul 3.

Flavivirus structural heterogeneity: implications for cell entry.

Author information

1
Structural Virology Unit, Virology Department, Institut Pasteur, 25-28 rue du Dr Roux, 75015 Paris, France; CNRS UMR 3569, 25-28 rue du Dr Roux, 75015 Paris, France. Electronic address: Felix.rey@pasteur.fr.
2
Center for Virology, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, Austria.
3
Center for Virology, Medical University of Vienna, Kinderspitalgasse 15, 1090 Vienna, Austria. Electronic address: Franz.X.Heinz@meduniwien.ac.at.

Abstract

The explosive spread of Zika virus is the most recent example of the threat imposed to human health by flaviviruses. High-resolution structures are available for several of these arthropod-borne viruses, revealing alternative icosahedral organizations of immature and mature virions. Incomplete proteolytic maturation, however, results in a cloud of highly heterogeneous mosaic particles. This heterogeneity is further expanded by a dynamic behavior of the viral envelope glycoproteins. The ensemble of heterogeneous and dynamic infectious particles circulating in infected hosts offers a range of alternative possible receptor interaction sites at their surfaces, potentially contributing to the broad flavivirus host-range and variation in tissue tropism. The potential synergy between heterogeneous particles in the circulating cloud thus provides an additional dimension to understand the unanticipated properties of Zika virus in its recent outbreaks.

PMID:
28683393
PMCID:
PMC6037290
DOI:
10.1016/j.coviro.2017.06.009
[Indexed for MEDLINE]
Free PMC Article

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