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Cell Metab. 2017 Jul 5;26(1):49-70. doi: 10.1016/j.cmet.2017.06.004.

Similarities and Distinctions of Cancer and Immune Metabolism in Inflammation and Tumors.

Author information

1
Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center and Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA.
2
Vanderbilt Center for Immunobiology, Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center and Department of Cancer Biology, Vanderbilt University, Nashville, TN 37232, USA. Electronic address: jeff.rathmell@vanderbilt.edu.

Abstract

It has been appreciated for nearly 100 years that cancer cells are metabolically distinct from resting tissues. More recently understood is that this metabolic phenotype is not unique to cancer cells but instead reflects characteristics of proliferating cells. Similar metabolic transitions also occur in the immune system as cells transition from resting state to stimulated effectors. A key finding in immune metabolism is that the metabolic programs of different cell subsets are distinctly associated with immunological function. Further, interruption of those metabolic pathways can shift immune cell fate to modulate immunity. These studies have identified numerous metabolic similarities between cancer and immune cells but also critical differences that may be exploited and that affect treatment of cancer and immunological diseases.

KEYWORDS:

T cell; antitumor immunity; glycolysis; inflammation; macrophage; mitochondria; tumor metabolism; tumor microenvironment

PMID:
28683294
PMCID:
PMC5555084
DOI:
10.1016/j.cmet.2017.06.004
[Indexed for MEDLINE]
Free PMC Article

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