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Neuron. 2017 Jul 5;95(1):19-32. doi: 10.1016/j.neuron.2017.05.021.

Toward a Neurocentric View of Learning.

Author information

1
Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA.
2
Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA; Department of Statistics, University of Chicago, Chicago, IL 60637, USA.
3
Department of Neurobiology, University of Chicago, Chicago, IL 60637, USA. Electronic address: chansel@bsd.uchicago.edu.

Abstract

Synaptic plasticity (e.g., long-term potentiation [LTP]) is considered the cellular correlate of learning. Recent optogenetic studies on memory engram formation assign a critical role in learning to suprathreshold activation of neurons and their integration into active engrams ("engram cells"). Here we review evidence that ensemble integration may result from LTP but also from cell-autonomous changes in membrane excitability. We propose that synaptic plasticity determines synaptic connectivity maps, whereas intrinsic plasticity-possibly separated in time-amplifies neuronal responsiveness and acutely drives engram integration. Our proposal marks a move away from an exclusively synaptocentric toward a non-exclusive, neurocentric view of learning.

KEYWORDS:

Purkinje cell; cerebellum; ensemble; hippocampus; intrinsic; memory engram; neocortex; plasticity; pyramidal cell; synaptic

PMID:
28683265
PMCID:
PMC5519140
DOI:
10.1016/j.neuron.2017.05.021
[Indexed for MEDLINE]
Free PMC Article

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