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PLoS One. 2017 Jul 6;12(7):e0179731. doi: 10.1371/journal.pone.0179731. eCollection 2017.

Physical activity domains and risk of gastric adenocarcinoma in the MCC-Spain case-control study.

Author information

1
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, Murcia, Spain.
2
CIBER Epidemiología y Salud Pública (CIBERESP), Madrid, Spain.
3
Department of Health and Social Sciences, University of Murcia, Murcia, Spain.
4
Research Group on Gene-Environment Interactions and Health, University of León, León, Spain.
5
Public Health Division of Gipuzkoa, BioDonostia Research Institute, Government of the Basque Country, San Sebastián, Spain.
6
Cancer Epidemiology Unit, National Center for Epidemiology, Instituto de Salud Carlos III, Madrid, Spain.
7
Cancer Epidemiology Research Group, Oncology and Hematology Area, IIS Puerta de Hierro, Madrid, Spain.
8
Cancer Prevention and Control Program, Catalan Institute of Oncology- IDIBELL, L'Hospitalet de Llobregat, Spain.
9
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
10
Navarra Public Health Institute, IdiSNA (Navarra Institute for Health Research), Pamplona, Spain.
11
Universidad de Cantabria-IDIVAL, Santander, Spain.
12
Department of Gastroenterology, Hospital Juan Ramón Jiménez, Huelva, Spain.
13
Centro de Investigación en Salud y Medio Ambiente (CYSMA), University of Huelva.
14
University of Oviedo-IUOPA, Oviedo, Spain.
15
Area de Cáncer y Salud Pública, Fundación FISABIO-Salud Pública, Valencia, Spain.
16
Department of Preventive Medicine and Public Health, University of Granada, Granada, Spain.
17
Instituto de Investigación Biosanitaria ibs, Granada, Complejo Hospitales Universitarios de Granada, University of Granada, Granada, Spain.
18
ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain.
19
IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.
20
Universitat Pompeu Fabra (UPF), Barcelona, Spain.

Abstract

BACKGROUND:

Evidence for a protective role of physical activity against development of stomach cancer is yet inconclusive. We studied the association of domain-specific physical activity and the risk of gastric adenocarcinoma (GAC), by site and histology, in the MCC-Spain case-control study.

METHODS:

428 histologically confirmed GAC cases (67% men) including the gastro-esophageal region and 3225 controls were included. Cases were recruited in hospitals from 10 different Spanish regions, whereas population controls were randomly selected within the respective hospitals' catchment areas. A physical activity (PA) questionnaire was used to gather information on household and recreational activities, allowing estimation of PA volume (in metabolic equivalents (MET)-min/week). Participants also reported the intensity of working PA and daily sitting time. Questionnaire data on diet, lifestyles and clinical variables including Helicobacter pylori serology were available. Adjusted odds ratios (OR) of GAC were estimated for domains of physical activity, stratifying by sex, site (cardia vs. non-cardia), and Lauren classification (intestinal vs. diffuse).

RESULTS:

Household physical activity (HPA) showed a strong inverse association with GAC, observed for both cardia and non-cardia tumours. Risk of overall gastric cancer was 50% lower risk among participants in the highest HPA category (OR = 0.50, 95%CI: 0.38, 0.66). Recreational physical activity (RPA) was also associated with lower overall GAC risk (OR = 0.68, 95% CI: 0.52, 0.88), particularly at moderate levels of intensity such as walking (OR = 0.61, 95% CI: 0.46, 0.79). The protective effect of RPA was strongest for non-cardia tumours. Sedentary time was not related to GAC risk (p-trend = 0.392), but the potential protective effect of RPA was restricted to non-sedentary participants.

CONCLUSIONS:

Both household and recreational physical activities were independently related to lower GAC risk in the MCC-Spain study.

PMID:
28683070
PMCID:
PMC5500262
DOI:
10.1371/journal.pone.0179731
[Indexed for MEDLINE]
Free PMC Article

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