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Pain. 2017 Sep;158(9):1831-1838. doi: 10.1097/j.pain.0000000000000985.

Brain imaging of pain sensitization in patients with knee osteoarthritis.

Author information

1
aMRI Research Unit, Department of Radiology, Hospital del Mar, Barcelona, Spain bCentro Investigación Biomédica en Red de Salud Mental, CIBERSAM G21, Barcelona, Spain cRheumatology Department, Hospital del Mar, Barcelona, Spain dMelbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne and Melbourne Health, Melbourne, Australia eDepartment of Anesthesiology, Cincinnati Children's Hospital, Cincinnati, OH, USA fDepartment of Clinical and Health Psychology, Autonomous University of Barcelona, Barcelona, Spain.

Abstract

A relevant aspect in osteoarthritic pain is neural sensitization. This phenomenon involves augmented responsiveness to painful stimulation and may entail a clinically worse prognosis. We used functional magnetic resonance imaging (fMRI) to study pain sensitization in patients with knee osteoarthritis. Sixty patients were recruited and pain sensitization was clinically defined on the basis of regional spreading of pain (spreading sensitization) and increased pain response to repeated stimulation (temporal summation). Functional magnetic resonance imaging testing involved assessing brain responses to both pressure and heat stimulation. Thirty-three patients (55%) showed regional pain spreading (simple sensitization) and 19 patients (32%) showed both regional spreading and temporal summation. Sensitized patients were more commonly women. Direct painful pressure stimulation of the joint (articular interline) robustly activated all of the neural elements typically involved in pain perception, but did not differentiate sensitized and nonsensitized patients. Painful pressure stimulation on the anterior tibial surface (sensitized site) evoked greater activation in sensitized patients in regions typically involved in pain and also beyond these regions, extending to the auditory, visual, and ventral sensorimotor cortices. Painful heat stimulation of the volar forearm did not discriminate the sensitization phenomenon. Results confirm the high prevalence of pain sensitization secondary to knee osteoarthritis. Relevantly, the sensitization phenomenon was associated with neural changes extending beyond strict pain-processing regions with enhancement of activity in general sensory, nonnociceptive brain areas. This effect is in contrast to the changes previously identified in primary pain sensitization in fibromyalgia patients presenting with a weakening of the general sensory integration.

PMID:
28683024
DOI:
10.1097/j.pain.0000000000000985
[Indexed for MEDLINE]

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