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Hua Xi Kou Qiang Yi Xue Za Zhi. 2017 Apr 1;35(2):215-220. doi: 10.7518/hxkq.2017.02.020.

[The origin of hydrogen peroxide in oral cavity and its role in oral microecology balance].

[Article in Chinese; Abstract available in Chinese from the publisher]

Author information

1
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.

Abstract

in English, Chinese

Hydrogen peroxide, an important antimicrobial agent in oral cavity, plays a significant role in the balance of oral microecology. At the early stage of biofilm formation, about 80% of the detected initial colonizers belong to the genus Streptococcus. These oral streptococci use different oxidase to produce hydrogen peroxide. Recent studies showed that the produced hydrogen peroxide plays a critical role in modulating oral microecology. Hydrogen peroxide modulates biofilm development attributed to its growth inhibitory nature. Hydrogen peroxide production is closely associated with extracellular DNA(eDNA) release from microbe and the development of its competent cell which are critical for biofilm development and also serves as source for horizontal gene transfer. Microbe also can reduce the damage to themselves through several detoxification mechanisms. Moreover, hydrogen peroxide is also involved in the regulation of interactions between oral microorganisms and host. Taken together, hydrogen peroxide is an imperative ecological factor that contributes to the microbial equilibrium in the oral cavity. Here we will give a brief review of both the origin and the function in the oral microecology balance of hydrogen peroxide.

KEYWORDS:

biofilm; hydrogen peroxide; microorganisms and host; oral microbe; oral microecology

PMID:
28682556
DOI:
10.7518/hxkq.2017.02.020
[Indexed for MEDLINE]
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