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Elife. 2017 Jul 6;6. pii: e25835. doi: 10.7554/eLife.25835.

Building bridges between cellular and molecular structural biology.

Author information

1
Cellular Structure and 3D Bioimaging, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
2
Visualization Sciences Group, FEI, Mérignac, France.
3
Institute of Biotechnology and the Department of Biosciences, University of Helsinki, Helsinki, Finland.
4
Electron Microscopy Science Technology Platform, Francis Crick Institute, London, United Kingdom.
5
Centre for Gene Regulation and Expression, University of Dundee, Dundee, United Kingdom.
6
Division of Structural Biology, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.
7
National Center for Macromolecular Imaging, Verna and Marrs McLean Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, United States.
8
Department of Molecular Cell Biology, Leiden University Medical Center, Leiden, The Netherlands.
9
European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
10
Center for Integrative Proteomics Research and the Research Collaboratory for Structural Bioinformatics, Rutgers, The State University of New Jersey, Piscataway, United States.
11
Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, United States.
12
Kitware, Inc., Carrboro, United States.
13
Molecular Archival Resources, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.
14
Structural Biology of Cells and Viruses, Francis Crick Institute, London, United Kingdom.
15
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States.
16
Institute of Structural and Molecular Biology, Department of Crystallography, Birkbeck College, London, United Kingdom.
17
Laboratory for Cell Biology, Center for Cancer Research, National Cancer Institute, Bethesda, United States.
18
Centre for Gene Regulation and Expression and the Division of Computational Biology, University of Dundee, Dundee, United Kingdom.
19
Scientific Computing Department, Science and Technology Facilities Council, Research Complex at Harwell, Didcot, United Kingdom.
20
Molecular and Cellular Structure Cluster, European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, United Kingdom.

Abstract

The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures.

KEYWORDS:

biophysics; computational biology; electron microscopy; emdb; empiar; none; ontology; segmentation; structural biology; systems biology; tomography

PMID:
28682240
PMCID:
PMC5524535
DOI:
10.7554/eLife.25835
[Indexed for MEDLINE]
Free PMC Article

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