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Chemistry. 2017 Jul 26;23(42):10215-10221. doi: 10.1002/chem.201701904. Epub 2017 Jul 6.

Thermal Stimuli-Triggered Drug Release from a Biocompatible Porous Metal-Organic Framework.

Author information

1
State Key Laboratory of Silicon Materials, Cyrus Tang Center for Sensor Materials and Applications, School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027, P. R. China.
2
Department of Pharmacology, School of Medicine, Hangzhou Normal University, Hangzhou, 310036, P. R. China.

Abstract

Drug delivery carriers with a high drug loading capacity and biocompatibility, especially for controlled drug release, are urgently needed due to the side effects and frequently dose in the traditional therapeutic method. In our work, a Zr-based metal-organic framework named ZJU-801, which is isoreticular with NU-801, has been designed and further demonstrated as an excellent drug delivery system (DDS) with a high drug loading of 41.7 %. Such a high drug loading capacity may be ascribed to the appropriate match of the size and the large pore volume of this kind of Zr MOF material. Compared with DS@NU-801, this DDS has successfully achieved on-command heating-activated drug release, which was probably attributed to the bulkier ligand, the better stability, and the intense π-π interaction between ZJU-801 and diclofenac sodium (DS) demonstrated comprehensively by SEM, powder X-ray diffraction (PXRD), FTIR and 13 C solid-state NMR spectroscopy as well as computer simulations. It is worth noting that premature drug release was avoided effectively without any complicated post-modifications. The low cytotoxicity and good biocompatibility of our DDS were certificated by the in vitro favorable results from an MTT assay, a WST-1 assay, and confocal microscopy imaging.

KEYWORDS:

drug carriers; drug delivery; medicinal chemistry; metal-organic frameworks; pi-pi interactions

PMID:
28682004
DOI:
10.1002/chem.201701904
[Indexed for MEDLINE]

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