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Photodermatol Photoimmunol Photomed. 2018 Jan;34(1):5-12. doi: 10.1111/phpp.12328. Epub 2017 Aug 8.

Melanoma and nonmelanoma skin cancer chemoprevention: A role for nicotinamide?

Author information

1
Discipline of Dermatology, Bosch Institute, Central Clinical School, University of Sydney, Sydney, NSW, Australia.
2
Dermatology, Sydney Cancer Centre, Royal Prince Alfred Hospital, Sydney, NSW, Australia.
3
Melanoma Institute Australia, North Sydney, NSW, Australia.

Abstract

Ultraviolet radiation (UVR) causes DNA damage in melanocytes by producing photolesions such as cyclobutane pyrimidine dimers and 8-oxo-7-hydrodeoxyguanosine. The production of reactive oxygen species by UVR also induces inflammatory cytokines that, together with the inherent immunosuppressive properties of UVR, propagate carcinogenesis. Nicotinamide (Vitamin B3 ) enhances DNA repair, modulates the inflammatory environment produced by UVR, and reduces UV-induced immunosuppression. As nicotinamide reduces the incidence of actinic keratoses and nonmelanoma skin cancers in high-risk individuals and enhances repair of DNA damage in melanocytes, it is a promising agent for the chemoprevention of melanoma in high-risk populations.

KEYWORDS:

niacinamide; nicotinamide; skin cancer

PMID:
28681504
DOI:
10.1111/phpp.12328

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