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Am J Clin Dermatol. 2017 Jul 5. doi: 10.1007/s40257-017-0300-2. [Epub ahead of print]

Probiotics, Prebiotics, and Synbiotics for the Treatment and Prevention of Adult Dermatological Diseases.

Author information

1
Department of Dermatology, UC Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA.
2
Drexel University College of Medicine, Philadelphia, PA, USA.
3
Department of Dermatology, UC Davis, 3301 C Street, Suite 1400, Sacramento, CA, 95816, USA. raja.sivamani.md@gmail.com.
4
Department of Biological Sciences, California State University - Sacramento, Sacramento, CA, USA. raja.sivamani.md@gmail.com.

Abstract

BACKGROUND:

Probiotic, prebiotic, and synbiotic supplementation is becoming more prevalent nowadays. Clinical studies have demonstrated some of the medical benefits of probiotics, prebiotics, and synbiotics within dermatology but an evidence-based review of their effects in adults is needed.

OBJECTIVE:

The aim of this study was to identify evidence for the use of supplementation with probiotics, prebiotics, or synbiotics for the prevention and treatment of dermatological diseases in adults.

DATA SOURCES:

We conducted a search of the Ovid MEDLINE, Cochrane Central Register of Controlled trials and EMBASE electronic databases from 1 January 1946 to 11 January 2017.

STUDY SELECTION:

Trials examining supplementation in the treatment of dermatological diseases using oral or topical probiotics, synbiotics, and prebiotics in adults over the age of 18 years were selected.

DATA EXTRACTION:

Of 315 articles, 12 met the inclusion criteria.

DATA SYNTHESIS:

Nutritional supplementation with probiotics and prebiotics was shown to improve atopic dermatitis (AD) symptomatology, quality of life, or clinical severity in six of nine studies. One study in psoriasis was shown to improve inflammatory markers, and one study suggested that probiotics could be used as adjunctive therapy in the treatment of acne.

CONCLUSION:

Preliminary studies are optimistic for the use of some strains of probiotics for symptomatic and clinical improvement in AD, and as adjunctive treatment with antibiotics for acne. Further research is necessary to better assess how probiotics and prebiotics may be used within dermatology.

PMID:
28681230
DOI:
10.1007/s40257-017-0300-2
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