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J Pharm Pharmacol. 1985 Dec;37(12):930-1.

Ascorbic acid antagonizes the behavioural effects of LSD in cats.


Pretreatment with ascorbic acid (500 mg kg-1 i.p.) antagonized the behavioural effects of lysergic acid diethylamide (LSD) and apomorphine, but not 5-methoxy-N,N-dimethyltryptamine, in cats. The data support the hypothesis that these behavioural effects in cats are due to drug action at both 5-HT and dopamine receptors, and that the action of LSD at dopamine receptors is modulated by ascorbic acid.

[Indexed for MEDLINE]

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