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Oncoimmunology. 2017 May 8;6(6):e1321187. doi: 10.1080/2162402X.2017.1321187. eCollection 2017.

Parallel profiling of immune infiltrate subsets in uveal melanoma versus cutaneous melanoma unveils similarities and differences: A pilot study.

Author information

1
Department of Melanoma Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
2
Department of Translational Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
3
Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
4
Department of Genomic Medicine, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
5
Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
6
Section of Ophthalmology, Department of Head and Neck Surgery and The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.
7
Orbital Oncology and Ophthalmic Plastic Surgery, Department of Plastic Surgery, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA.

Abstract

The low response rates to immunotherapy in uveal melanoma (UM) sharply contrast with reputable response rates in cutaneous melanoma (CM) patients. To characterize the mechanisms responsible for resistance to immunotherapy in UM, we performed immune profiling in tumors from 10 metastatic UM patients and 10 metastatic CM patients by immunohistochemistry (IHC). Although there is no difference in infiltrating CD8+ T cells between UM and CM, a significant decrease in programmed death-1 (PD-1)-positive lymphocytes was observed and lower levels of programmed death ligand-1 (PD-L1) in UM metastases compared with CM metastases. Tumors from metastatic UM patients showed a lower success rate of tumor-infiltrating lymphocyte (TIL) growth compared with metastatic CM (45% vs. 64% success), with a significantly lower quantity of UM TIL expanded overall. These studies suggest that UM and CM are immunologically distinct, and provide potential explanation for the impaired success of immunotherapy in UM.

KEYWORDS:

Cutaneous melanoma; immune profile; tumor infiltrating lymphocytes; uveal melanoma

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