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Cent Eur J Immunol. 2017;42(1):10-16. doi: 10.5114/ceji.2017.67313. Epub 2017 May 8.

The effect of feeding mice during gestation and nursing with Rhodiola kirilowii extracts or epigallocatechin on CD4 and CD8 cells number and distribution in the spleen of their progeny.

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Department of Regenerative Medicine and Cell Biology, Military Institute of Hygiene and Epidemiology, Poland.
Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Pathomorphology Department, Center for Biostructure Research, Warsaw Medical University, Warsaw, Poland.


Rhodiola kirilowii, a member of Crassulaceae family, grows wildly in Asiatic mountains and is also cultivated in some European countries. Its underground parts traditionally are used for enhance physical and mental performance of the body. In our previous papers we reported immuno- and angio-modulatory effects of aqueous and hydro-alcoholic extracts of radix and rhizome of this plant in mice. In the present work we evaluated the effect of Rhodiola kirilowii water- (RKW) or hydro-alcoholic (RKW-A) extracts and epigallocatechin (one of the polyphenols present in these extracts) given to mice, during pregnancy and nursing period, on the number and localization of CD4+ and CD8+ cells in spleens of adult progeny mice. Previously, we observed several abnormalities in functionality of spleen cells collected from these mice. No differences in CD4+ T cells localisation or numbers were found between all tested mice groups. In contrast, CD8+ T cells localisation and staining were altered in progeny of water or alcohol extract-fed mice. CD8+ T cells were found not only in the PALS but also in the B cell follicle and in the red pulp. Furthermore, CD8+ T cells from T cell zones in the progeny of extract-fed mice showed much intensive staining for CD8 antigen and significantly higher numbers per area in comparison to control mice.


Rhodiola kirilowii; epigallocatechin; mice; progeny; spleen

Conflict of interest statement

The authors declare no conflict of interest.

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