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Exp Neurobiol. 2017 Jun;26(3):172-177. doi: 10.5607/en.2017.26.3.172. Epub 2017 Jun 20.

An Autopsy Proven Child Onset Chronic Traumatic Encephalopathy.

Lee K1, Kim SI1, Lee Y1, Won JK1,2, Park SH1,2,3.

Author information

1
Department of Pathology, Seoul National University Hospital, College of Medicine, Seoul, 03080, Korea.
2
Brain Bank, Seoul National University Hospital, College of Medicine, Seoul, 03080, Korea.
3
Neuroscience Research Institute, Seoul National University, Seoul, 03080, Korea.

Abstract

Here we present an autopsy case of chronic traumatic encephalopathy (CTE) in a 36-year-old man. He had a history of febrile seizures at the age of four and was severely demented at age 10 when he was admitted to a mental hospital. He had suffered repetitive self-harm, such as frequent banging of the head on the wall in his hospital record, but he had no clear history between the ages of four and ten. Autopsy revealed global cerebral atrophy, including the basal ganglia, thalamus, hippocampus, amygdala, mammilary bodies and lateral geniculate bodies. This case showed typical pathological features of CTE. Phosphorylated tau (p-tau)-positive neurofibrillary tangles (NFTs) and neuropil threads (NT) we are widely distributed in the brain, especially in the depth of the cerebral sulci. NFT and NT were also found in the basal ganglia, thalamus, amygdala and brainstem. Scanty β-amyloid deposits were found in the motor and sensory cortices, but α-synuclein was completely negative in the brain. This example showed that CTE can occur in young ages and that even children can experience CTE dementia.

KEYWORDS:

Pathology; Traumatic encephalopathy; children; chronic; dementia

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