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J R Soc Interface. 2017 Jul;14(132). pii: 20170028. doi: 10.1098/rsif.2017.0028.

A cell-based mechanical model of coronary artery tunica media.

Author information

1
Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, Saint Petersburg, Russia naunat@mail.ru.
2
Peter the Great State Polytechnic University, Saint Petersburg, Russia.
3
Saint Petersburg National Research University of Information Technologies, Mechanics and Optics, Saint Petersburg, Russia.
4
University of Sheffield, Sheffield, UK.
5
University of Amsterdam, Amsterdam, The Netherlands.

Abstract

A three-dimensional cell-based mechanical model of coronary artery tunica media is proposed. The model is composed of spherical cells forming a hexagonal close-packed lattice. Tissue anisotropy is taken into account by varying interaction forces with the direction of intercellular connection. Several cell-centre interaction potentials for repulsion and attraction are considered, including the Hertz contact model and its neo-Hookean extension, the Johnson-Kendall-Roberts model of adhesive contact, and a wormlike chain model. The model is validated against data from in vitro uni-axial tension tests performed on dissected strips of tunica media. The wormlike chain potential in combination with the neo-Hookean Hertz contact model produces stress-stretch curves which represent the experimental data very well.

KEYWORDS:

cell-based model; in silico stretch tests; mechanics; smooth muscle cell; tunica media

PMID:
28679664
PMCID:
PMC5550961
DOI:
10.1098/rsif.2017.0028
[Indexed for MEDLINE]
Free PMC Article

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