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EMBO J. 2017 Aug 1;36(15):2177-2181. doi: 10.15252/embj.201797606. Epub 2017 Jul 5.

Mitochondrial genome inheritance and replacement in the human germline.

Author information

1
Center for Embryonic Cell and Gene Therapy, Oregon Health & Science University, Portland, OR, USA.
2
Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA.

Abstract

Mitochondria, the ubiquitous power packs in nearly every eukaryotic cell, contain their own DNA, known as mtDNA, which is inherited exclusively from the mother. The number of mitochondrial genomes varies depending on the cell's energy needs. The mature oocyte contains the highest number of mitochondria of any cell type, although there is little if any mtDNA replication after fertilization until the embryo implants. This has potential repercussions for mitochondrial replacement therapy (MRT; see description of currently employed methods below) used to prevent the transmission of mtDNA-based disorders. If only a few mitochondria with defective mtDNA are left in the embryo and undergo extensive replication, it might therefore thwart the purpose of MRT In order to improve the safety and efficacy of this experimental therapy, we need a better understanding of how and which mtDNA is tagged for replication versus transcription after fertilization of the oocyte.

PMID:
28679504
PMCID:
PMC5538763
DOI:
10.15252/embj.201797606
[Indexed for MEDLINE]
Free PMC Article

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