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PLoS One. 2017 Jul 5;12(7):e0180347. doi: 10.1371/journal.pone.0180347. eCollection 2017.

Molecular characteristics of mcr-1-carrying plasmids and new mcr-1 variant recovered from polyclonal clinical Escherichia coli from Argentina and Canada.

Author information

1
Public Health Ontario Laboratory, Toronto, Ontario, Canada.
2
Servicio Antimicrobianos, National and Regional Reference Laboratory in Antimicrobial Resistance, Instituto Nacional de Enfermedades Infecciosas (INEI)-ANLIS "Dr. C. Malbran", Buenos Aires, Argentina.
3
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Buenos Aires, Argentina.
4
Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada.

Abstract

We have characterized nine mcr-1-harboring plasmids from clinical Escherichia coli isolates previously described in Argentina and Canada. Three of these plasmids carried a mcr-1-variant called here mcr-1.5. All these E. coli isolates were not clonally related and were recovered in different years and locations. However, their mcr-1-harboring plasmids showed high identity among them and to others characterized in other countries, which strongly suggests that this plasmid-type is playing an important role in spreading this mechanism of resistance to polymyxins.

PMID:
28678874
PMCID:
PMC5498056
DOI:
10.1371/journal.pone.0180347
[Indexed for MEDLINE]
Free PMC Article

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