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Semin Ophthalmol. 2018;33(4):560-565. doi: 10.1080/08820538.2017.1340487. Epub 2017 Jul 5.

Visual Outcomes in Japanese Patients with Retinitis Pigmentosa and Usher Syndrome Caused by USH2A Mutations.

Author information

1
a Department of Ophthalmology , Hamamatsu University School of Medicine , Hamamatsu-shi , Shizuoka , Japan.
2
b Department of Otorhinolaryngology/Head & Neck Surgery , Hamamatsu University School of Medicine , Hamamatsu-shi , Shizuoka , Japan.
3
c Department of Photomedical Genomics, Institute for Medical Photonics Research, Preeminent Medical Photonics Education & Research Center , Hamamatsu University School of Medicine , Hamamatsu-shi , Shizuoka , Japan.

Abstract

PURPOSE:

EYS and USH2A are the most common causative genes for retinitis pigmentosa (RP) in Japan. We determined the clinical outcomes for USH2A-related non-syndromic RP or Usher syndrome type II (USH2).

METHODS:

Two non-syndromic RP and 11 USH2 patients with previously identified USH2A mutations were included. Their complete history and medical records were collected using standard procedures. Visual fields and acuity were compared with those of patients with EYS mutations. Clinical analyses were based on ophthalmic and otolaryngologic examinations.

RESULTS:

In all patients, the fundus displayed changes typical of RP. Most patients showed relatively well-preserved visual acuity in their thirties or forties, with rapid deterioration in their fifties. Concentric constriction started in the twenties or thirties, and no effective residual visual field was observed after the fifties.

CONCLUSIONS:

The visual outcome for non-syndromic RP or USH2 patients with USH2A mutations is consistent with that for RP patients with EYS mutations.

KEYWORDS:

EYS gene; genetic disorder; hearing impairment; non-syndromic retinitis pigmentosa; rod-cone dysfunction

PMID:
28678594
DOI:
10.1080/08820538.2017.1340487
[Indexed for MEDLINE]

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