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Int J Mol Sci. 2017 Jul 5;18(7). pii: E1446. doi: 10.3390/ijms18071446.

Multifaceted Interpretation of Colon Cancer Stem Cells.

Author information

1
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. yuha@gifu-u.ac.jp.
2
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. u2001087@edu.gifu-u.ac.jp.
3
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. y3f3f84d72xsx@yahoo.co.jp.
4
Division of Animal Experiment, Life Science Research Center, Gifu University, 1-1 Yanagido, Gifu 501-1194, Japan. akatsuki@gifu-u.ac.jp.
5
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. ahara@gifu-u.ac.jp.
6
Department of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan. h_tomita@gifu-u.ac.jp.

Abstract

Colon cancer is one of the leading causes of cancer-related deaths worldwide, despite recent advances in clinical oncology. Accumulating evidence sheds light on the existence of cancer stem cells and their role in conferring therapeutic resistance. Cancer stem cells are a minor fraction of cancer cells, which enable tumor heterogeneity and initiate tumor formation. In addition, these cells are resistant to various cytotoxic factors. Therefore, elimination of cancer stem cells is difficult but essential to cure the malignant foci completely. Herein, we review the recent evidence for intestinal stem cells and colon cancer stem cells, methods to detect the tumor-initiating cells, and clinical significance of cancer stem cell markers. We also describe the emerging problems of cancer stem cell theory, including bidirectional conversion and intertumoral heterogeneity of stem cell phenotype.

KEYWORDS:

bidirectional conversion; cancer stem cell; colon cancer; epigenetics; genetics; intestinal stem cell; tumor heterogeneity

PMID:
28678194
PMCID:
PMC5535937
DOI:
10.3390/ijms18071446
[Indexed for MEDLINE]
Free PMC Article

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