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Eur J Neurosci. 2018 May;47(10):1148-1158. doi: 10.1111/ejn.13638. Epub 2017 Jul 20.

Striatal cholinergic interneurons and Parkinson's disease.

Author information

1
Department of Physiology, Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.

Abstract

Giant, aspiny cholinergic interneurons (ChIs) have long been known to be key nodes in the striatal circuitry controlling goal-directed actions and habits. In recent years, new experimental approaches, like optogenetics and monosynaptic rabies virus mapping, have expanded our understanding of how ChIs contribute to the striatal activity underlying action selection and the interplay of dopaminergic and cholinergic signaling. These approaches also have begun to reveal how ChI function is distorted in disease states affecting the basal ganglia, like Parkinson's disease (PD). This review gives a brief overview of our current understanding of the functional role played by ChIs in striatal physiology and how this changes in PD. The translational implications of these discoveries, as well as the gaps that remain to be bridged, are discussed as well.

KEYWORDS:

G-protein-coupled receptor; dopamine; dyskinesia; electrophysiology; neuromodulation; striatum

PMID:
28677242
PMCID:
PMC6074051
DOI:
10.1111/ejn.13638
[Indexed for MEDLINE]
Free PMC Article

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