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Eur Radiol. 2017 Dec;27(12):5094-5103. doi: 10.1007/s00330-017-4933-6. Epub 2017 Jul 4.

Repeatability of apparent diffusion coefficient and intravoxel incoherent motion parameters at 3.0 Tesla in orbital lesions.

Author information

1
Department of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, 29 rue Manin, 75019, Paris, France. alecler@for.paris.
2
Université Paris Descartes Sorbonne Paris Cité, INSERM UMR-S970, Cardiovascular Research Centre - PARCC, Paris, France. alecler@for.paris.
3
Department of Radiology, Fondation Ophtalmologique Adolphe de Rothschild, 29 rue Manin, 75019, Paris, France.
4
Université Paris Descartes Sorbonne Paris Cité, INSERM UMR-S970, Cardiovascular Research Centre - PARCC, Paris, France.
5
Department of Orbitopalpebral Surgery, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
6
Clinical Research Unit, Fondation Ophtalmologique Adolphe de Rothschild, Paris, France.
7
Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, Radiology Department, Université Paris Descartes Sorbonne Paris Cité, Paris, France.

Abstract

OBJECTIVES:

To evaluate repeatability of intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) parameters in the orbit.

METHODS:

From December 2015 to March 2016, 22 patients were scanned twice using an IVIM sequence with 15b values (0-2,000 s/mm2) at 3.0T. Two readers independently delineated regions of interest in an orbital mass and in different intra-orbital and extra-orbital structures. Short-term test-retest repeatability and inter-observer agreement were assessed using the intra-class correlation coefficient (ICC), the coefficient of variation (CV) and Bland-Altman limits of agreements (BA-LA).

RESULTS:

Test-retest repeatability of IVIM parameters in the orbital mass was satisfactory for ADC and D (mean CV 12% and 14%, ICC 95% and 93%), poor for f and D*(means CV 43% and 110%, ICC 90% and 65%). Inter-observer repeatability agreement was almost perfect in the orbital mass for all the IVIM parameters (ICC = 95%, 93%, 94% and 90% for ADC, D, f and D*, respectively).

CONCLUSIONS:

IVIM appeared to be a robust tool to measure D in orbital lesions with good repeatability, but this approach showed a poor repeatability of f and D*.

KEY POINTS:

• IVIM technique is feasible in the orbit. • IVIM has a good-acceptable repeatability of D (CV range 12-25 %). • IVIM interobserver repeatability agreement is excellent (ICC range 90-95 %). • f or D* provide higher test-retest and interobserver variabilities.

KEYWORDS:

DWI; Feasibility; IVIM; MRI; Orbit

PMID:
28677061
PMCID:
PMC5674133
DOI:
10.1007/s00330-017-4933-6
[Indexed for MEDLINE]
Free PMC Article

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