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Exp Clin Endocrinol Diabetes. 2018 Jan;126(1):61-65. doi: 10.1055/s-0043-109700. Epub 2017 Jul 4.

Risk Factors for Premature Death in Diabetes Patients who Undergo Amputations below Ankle Level.

[Article in German]

Author information

1
Department of Endocrinology, University of Copenhagen, Bispebjerg Hospital, Denmark.
2
Copenhagen Diabetes Foot Center, University of Copenhagen, Bispebjerg Hospital, Denmark.
3
Copenhagen Wound Healing Center, University of Copenhagen, Bispebjerg Hospital, Denmark.

Abstract

AIM:

To identify risk factors for early death in diabetes patients who undergo amputations below the ankle.

METHODS:

A retrospective study, where all hospital records of all diabetes patients who had undergone minimum one amputation below the ankle at the CWHC Bispebjerg Hospital, Denmark, in the period 1996-2013, were examined. The amputations were mainly trans-metatarsal amputations and partial amputations of toes. The participants were found via ICD10-codes. The included patients were followed from their first contact to the last registered contact. The statistical analysis in this article is performed on patients with a of minimum 5-year follow-up.

RESULTS:

The 5 year mortality was 42% for patients with type 2 diabetes, and 29% for patients with type 1 diabetes. For patients with type 2 diabetes, multivariable analysis showed that high age, peripheral arterial insufficiency and short time from first admission to amputation were independently statistically significantly associated with increased 5-years mortality. Use of statins was associated with decreased mortality. 35% died as a result of their diabetes, mostly due to cardiovascular causes.

CONCLUSION:

Short time from first admission to amputation is a risk factor for early death. Arterial insufficiency and high age is also associated with increased mortality, whereas use of statin is associated with decreased mortality, in patients with type 2 diabetes.

PMID:
28675915
DOI:
10.1055/s-0043-109700
[Indexed for MEDLINE]

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