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Arch Dermatol Res. 2017 Sep;309(7):499-517. doi: 10.1007/s00403-017-1751-2. Epub 2017 Jul 3.

The relevance of serum vitamin D in psoriasis: a review.

Author information

1
Department of Dermatology, The Charles Centre, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland. roisinhambly@gmail.com.
2
Department of Dermatology, The Charles Centre, St Vincent's University Hospital, Elm Park, Dublin 4, Ireland.
3
University College Dublin School of Medicine and Medical Sciences, Dublin 4, Ireland.

Abstract

Observational research has identified low serum levels of 25-hydroxyvitamin D (25[OH]D) in many non-skeletal diseases. Whether this is causal or due to underlying illness is unknown. Low serum 25[OH]D levels are also reported in the general population. Observational and experimental studies identify that vitamin D supplementation may be beneficial in reducing all-cause mortality in elderly women, as well as cancer mortality. Our aim was to review the literature to identify the relevance of serum 25[OH]D levels in psoriasis. Forty-five studies were included in our analysis. Most of these studies identified low serum 25[OH]D levels in psoriasis patients. Evidence of causality is lacking. Treatment with phototherapy leads to an increase in serum 25[OH]D. There is little evidence that the increase in 25[OH]D after phototherapy correlates with improved disease severity. Multiple studies report an improvement in psoriasis with vitamin D supplementation. These data are predominantly from small observational or non-randomised interventional studies. Randomised controlled trials to date have had small numbers and short follow-up periods. The optimal dose of supplementation is unknown and dosing is not standardised across different studies. The definition of vitamin D insufficiency varies across studies. Low serum 25[OH]D levels may be associated with comorbidities in psoriasis patients, including metabolic syndrome and cardiovascular risk. Evidence of causation is absent. Until further high-quality evidence is available, the relevance of low serum 25[OH]D levels in psoriasis patients is unknown, as is the benefit of supplementation on disease control. Supplementation in patients with low 25[OH]D is of benefit to those at risk of impaired bone health.

KEYWORDS:

25(OH)D; 25-Hydroxyvitamin D; Psoriasis; Vitamin D

PMID:
28674914
DOI:
10.1007/s00403-017-1751-2
[Indexed for MEDLINE]

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