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Int Urol Nephrol. 2018 Mar;50(3):495-500. doi: 10.1007/s11255-017-1647-2. Epub 2017 Jul 3.

Icodextrin and peritoneal dialysis: advantages and new applications.

Author information

1
Hemodialysis Unit Kyanous Stavros Patras, Germanou 115, 26225, Patras, Greece. dousdampanis@yahoo.gr.
2
Ageing Biology Unit, Nephrology Division, Italian Hospital of Buenos Aires, Buenos Aires, Argentina.
3
Hemodialysis Unit Kyanous Stavros Patras, Germanou 115, 26225, Patras, Greece.

Abstract

The impact of icodextrin (ico) on peritoneal dialysis (PD) extension and patient survival is well established. Predominantly, ico-based solutions were prescribed in high-transporter PD patients. Advantages of the ico-based solutions include increased biocompatibility, avoidance of glucotoxicity, enhanced ultrafiltration failure (UF), sodium removal rates, better metabolic and blood pressure control. Bimodal solutions and twice daily exchanges of ico-based solutions are two newly introduced strategies to avoid glucose exposure and/or enhance UF in PD patients with UF failure. In addition, a simplified schedule of PD using a single nocturnal exchange of ico in patients with refractory congestive heart failure may represent an alternative option to manage fluid removal and azotaemia. The use of a simplified schedule of PD with only two ico exchanges or a single ico exchange is a challenging approach for end-stage renal disease patients with preserved residual function who desire to initiate PD.

KEYWORDS:

Bimodal solutions; Congestive heart failure; Icodextrin; Peritoneal dialysis; Utrafiltration failure

PMID:
28674854
DOI:
10.1007/s11255-017-1647-2

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