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Viruses. 2017 Jun 26;9(7). pii: E160. doi: 10.3390/v9070160.

HHV-6A/B Integration and the Pathogenesis Associated with the Reactivation of Chromosomally Integrated HHV-6A/B.

Author information

1
Division of Infectious and Immune Diseases, CHU de Quebec Research Center-Laval University, Québec, QC G1V 4G2, Canada. Vanessa.Collin.2@ulaval.ca.
2
Division of Infectious and Immune Diseases, CHU de Quebec Research Center-Laval University, Québec, QC G1V 4G2, Canada. Louis.Flamand@crchudequebec.ulaval.ca.
3
Department of Microbiology, Infectious Disease and Immunology, Faculty of Medicine, Laval University, Québec, QC G1V 0A6, Canada. Louis.Flamand@crchudequebec.ulaval.ca.

Abstract

Unlike other human herpesviruses, human herpesvirus 6A and 6B (HHV-6A/B) infection can lead to integration of the viral genome in human chromosomes. When integration occurs in germinal cells, the integrated HHV-6A/B genome can be transmitted to 50% of descendants. Such individuals, carrying one copy of the HHV-6A/B genome in every cell, are referred to as having inherited chromosomally-integrated HHV-6A/B (iciHHV-6) and represent approximately 1% of the world's population. Interestingly, HHV-6A/B integrate their genomes in a specific region of the chromosomes known as telomeres. Telomeres are located at chromosomes' ends and play essential roles in chromosomal stability and the long-term proliferative potential of cells. Considering that the integrated HHV-6A/B genome is mostly intact without any gross rearrangements or deletions, integration is likely used for viral maintenance into host cells. Knowing the roles played by telomeres in cellular homeostasis, viral integration in such structure is not likely to be without consequences. At present, the mechanisms and factors involved in HHV-6A/B integration remain poorly defined. In this review, we detail the potential biological and medical impacts of HHV-6A/B integration as well as the possible chromosomal integration and viral excision processes.

KEYWORDS:

human herpesvirus 6A/B; inherited chromosomally-integrated HHV-6A/B; integration; reactivation; telomere

PMID:
28672870
PMCID:
PMC5537652
DOI:
10.3390/v9070160
[Indexed for MEDLINE]
Free PMC Article

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