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PLoS One. 2017 Jul 3;12(7):e0180356. doi: 10.1371/journal.pone.0180356. eCollection 2017.

APOE ε4-TOMM40 '523 haplotypes and the risk of Alzheimer's disease in older Caucasian and African Americans.

Author information

1
Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, United States of America.
2
Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, United States of America.
3
Department of Neurology, Duke University School of Medicine, Durham, North Carolina, United States of America.
4
Zinfandel Pharmaceuticals, Inc., Research Triangle Park, North Carolina, United States of America.
5
Center for Translational and Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, New York, United States of America.
6
Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, United States of America.

Abstract

Patterns of linkage between the ε4 allele of Apolipoprotein E (APOE) and '523 poly-T alleles in the adjacent gene, TOMM40, differ between Caucasian and African Americans. The extent to which this difference affects the risk of Alzheimer's disease (AD) is unclear. We compared the APOE ε4-TOMM40 '523 haplotypes between older Caucasian and African Americans, and examined their relationship with AD dementia. Data came from three community based cohort studies of diverse participants. APOE genotypes were determined by polymorphisms of rs429358 and rs7412. TOMM40 '523 genotypes were defined by the poly-T repeat length of rs10524523 (short ['523-S]: poly-T ≤ 19, long ['523-L]: 20 ≤ poly-T ≤ 29, and very long ['523-VL]: poly-T ≥ 30). Cox proportional hazards models examined the effect of haplotype variation on the risk of incident AD dementia. A total of 1,848 Caucasian and 540 African American individuals were included in the study. In Caucasians, nearly none (0.8%) of the non-ε4 carriers and almost all (94.2%) of the ε4 carriers had '523-L. The classification was highly concordant. Each ε4 allele doubled the risk for AD dementia and the dose effect was evident. Almost identical effect size and effect pattern were observed for TOMM40 '523-L. In African Americans, nearly none (1.1%) of the non-ε4 carriers had '523-L, but only 47.8% of the ε4 carriers had '523-L. The concordance was weaker compared with Caucasians. The effect patterns on incident AD dementia differed distinctively between ε4 and '523-L carriers. Further, both genotypic and allelic data support that among African Americans the ε4-'523-L haplotype had stronger effect on risk of AD dementia than other ε4-'523 haplotypes.

PMID:
28672022
PMCID:
PMC5495438
DOI:
10.1371/journal.pone.0180356
[Indexed for MEDLINE]
Free PMC Article

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