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Indian J Endocrinol Metab. 2017 Jul-Aug;21(4):551-554. doi: 10.4103/ijem.IJEM_412_16.

Increased Levels of Serum Interleukin-17 in Patients with Hashimoto's Thyroiditis.

Author information

1
Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
2
Department of Endocrinology, Imam Khomeini General Hospital, Tehran, Iran.
3
Department of Immunology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran.

Abstract

BACKGROUND:

CD4+ T-cells play important roles in the pathogenesis of Hashimoto's thyroiditis (HT). However, there is limited data about characteristics and function of the newly interleukin (IL)-17-producing T-helper cells in this common autoimmune thyroid disorder.

AIM:

The purpose of this study was to assess the levels of T-helper 17-related cytokines in sera of patients with HT.

MATERIALS AND METHODS:

Cytokine concentrations were measured in 48 patients with overt (n = 23) and subclinical hypothyroidism (25) and 35 healthy controls using enzyme-linked immunosorbent assay.

RESULTS:

The serum levels of IL-17 were significantly higher in patients than controls (P = 0.001) while no differences were observed with regard to levels of IL-22 and IL-23 between patients and normal controls.

CONCLUSION:

These results suggest that IL-17 could play some role in the pathogenesis of HT.

KEYWORDS:

Autoimmunity; Hashimoto's thyroiditis; T-lymphocyte; cytokine

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