Format

Send to

Choose Destination
Neuroimage. 2017 Sep;158:48-57. doi: 10.1016/j.neuroimage.2017.06.048. Epub 2017 Jun 29.

Modulation of cognitive cerebello-cerebral functional connectivity by lateral cerebellar continuous theta burst stimulation.

Author information

1
Division of Neurology, Department of Medicine, University of Toronto, Division of Brain, Imaging and Behavior - Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada.
2
Division of Neurology, Department of Medicine, University of Toronto, Division of Brain, Imaging and Behavior - Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada; Monash Alfred Psychiatry Research Centre, Monash University Central Clinical School and The Alfred, Melbourne, 3004, Australia.
3
Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada; MRI-Guided rTMS Clinic, Department of Psychiatry, University Health Network, Toronto, Ontario, M5T 2S8, Canada; Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada.
4
Division of Neurology, Department of Medicine, University of Toronto, Division of Brain, Imaging and Behavior - Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada.
5
Division of Neurology, Department of Medicine, University of Toronto, Division of Brain, Imaging and Behavior - Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada; Department of Neurology & Neurological Sciences, Stanford University, Stanford, CA, 94305, USA.
6
Division of Neurology, Department of Medicine, University of Toronto, Division of Brain, Imaging and Behavior - Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada; MRI-Guided rTMS Clinic, Department of Psychiatry, University Health Network, Toronto, Ontario, M5T 2S8, Canada; Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada.
7
Heart and Stroke Foundation Canadian Partnership for Stroke Recovery, Hurvitz Brain Sciences Program, Sunnybrook Research Institute, Toronto, Ontario, M4N 3M5, Canada; Department of Physical Therapy, University of Toronto, Toronto, Ontario, M5G 1V7, Canada.
8
Division of Neurology, Department of Medicine, University of Toronto, Division of Brain, Imaging and Behavior - Systems Neuroscience, Krembil Research Institute, University Health Network, Toronto, Ontario, M5T 2S8, Canada; Institute of Medical Science, Faculty of Medicine, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address: robert.chen@uhn.ca.

Abstract

Network connectivity measured with resting state functional magnetic resonance imaging (rsfMRI) has revealed the contribution of distinct cerebellar lobules to an array of brain wide networks sub-serving motor and cognitive processes. As distinct cerebellar lobules form relatively accessible nodes of different brain networks, this raises the possibility for site-specific modulation of network connectivity using non-invasive brain stimulation techniques such as transcranial magnetic stimulation (TMS). Continuous theta burst transcranial magnetic stimulation (cTBS) induces long-lasting inhibition of cortical areas. Although previous studies have shown that cTBS of the lateral cerebellum modulates motor cortical excitability and improves symptoms in several movement disorders, the effect on cognitive domains has not been examined. We explored the immediate effects of cTBS in a sham-controlled study on the strength of intrinsic functional connectivity between cerebellar and cortical motor and cognitive regions in 12 participants. Lateral cerebellar cTBS significantly decreased functional connectivity with frontal and parietal cognitive regions, while connectivity with motor regions remained unaltered. Sham stimulation had no effect on either motor or cognitive connectivity. These results show that inhibitory cerebellar stimulation reduces intrinsic functional connectivity between different cortical areas, in keeping with the known connectivity pattern of the cerebellum. The results highlight the plasticity of cerebello-cerebral networks and indicate for the first time that this functional connectivity can be downregulated using an inhibitory neurostimulation paradigm. This may shed light on the pathophysiology of network dysfunction and is a potential treatment for cognitive and movement disorders.

KEYWORDS:

Cerebellum; Cognition; Functional connectivity; Resting state functional magnetic resonance imaging; Transcranial magnetic stimulation

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center