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Curr Biol. 2017 Jul 10;27(13):2029-2035.e5. doi: 10.1016/j.cub.2017.05.086. Epub 2017 Jun 29.

Y Chromosome Uncovers the Recent Oriental Origin of Modern Stallions.

Author information

1
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna 1210, Austria. Electronic address: barbara.wallner@vetmeduni.ac.at.
2
Institut für Populationsgenetik, University of Veterinary Medicine Vienna, Vienna 1210, Austria; Institute of Parasitology, University of Veterinary Medicine Vienna, Vienna 1210, Austria.
3
Institute of Animal Breeding and Genetics, University of Veterinary Medicine Vienna, Vienna 1210, Austria.
4
Institute of Genetics, Vetsuisse Faculty, University of Bern, Bern 3001, Switzerland.
5
Lehrstuhl für Tierzucht, Technische Universität München, Freising 85354, Germany.
6
Institute of Animal Breeding and Husbandry, University of Kiel, Kiel 24098, Germany; Functional Breeding Group, Department of Animal Sciences, Georg-August-University Göttingen, Göttingen 37077, Germany.
7
Institute of Animal Breeding and Husbandry, University of Kiel, Kiel 24098, Germany.
8
Institute for Animal Breeding and Genetics, University of Veterinary Medicine Hannover, Hannover 30559, Germany.
9
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala 75007, Sweden.
10
Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala 75123, Sweden.
11
Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala 75007, Sweden; Department of Medical Biochemistry and Microbiology, Science for Life Laboratory, Uppsala University, Uppsala 75123, Sweden; Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4461, USA.
12
Veterinary Population Medicine Department, University of Minnesota, St. Paul, MN 55108, USA.
13
Agroscope, Swiss National Stud Farm, Avenches 1580, Switzerland.
14
Institut für Populationsgenetik, University of Veterinary Medicine Vienna, Vienna 1210, Austria.

Abstract

The Y chromosome directly reflects male genealogies, but the extremely low Y chromosome sequence diversity in horses has prevented the reconstruction of stallion genealogies [1, 2]. Here, we resolve the first Y chromosome genealogy of modern horses by screening 1.46 Mb of the male-specific region of the Y chromosome (MSY) in 52 horses from 21 breeds. Based on highly accurate pedigree data, we estimated the de novo mutation rate of the horse MSY and showed that various modern horse Y chromosome lineages split much later than the domestication of the species. Apart from few private northern European haplotypes, all modern horse breeds clustered together in a roughly 700-year-old haplogroup that was transmitted to Europe by the import of Oriental stallions. The Oriental horse group consisted of two major subclades: the Original Arabian lineage and the Turkoman horse lineage. We show that the English Thoroughbred MSY was derived from the Turkoman lineage and that English Thoroughbred sires are largely responsible for the predominance of this haplotype in modern horses.

KEYWORDS:

Equus caballus; Y chromosome; breeding; genealogy; haplotype; horse; patrilineal ancestry; phylogeny; stallion line

PMID:
28669755
DOI:
10.1016/j.cub.2017.05.086
[Indexed for MEDLINE]
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