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Anticancer Res. 2017 Jul;37(7):3729-3733.

Radiosurgery with a Rotating Gamma System: A Very Effective Treatment for Symptomatic Cerebral Cavernomas.

Author information

1
The Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam phamcamphuong@gmail.com.
2
The Nuclear Medicine and Oncology Center, Bach Mai Hospital, Hanoi, Vietnam.
3
Department of Radiation Oncology, Mayo Clinic, Scottsdale, AZ, U.S.A.
4
Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
5
Department of Nuclear Medicine, Ha Noi Medical University, Hanoi, Vietnam.

Abstract

AIM:

To evaluate the value of radiosurgery with a rotating gamma-system (RGS) for cerebral cavernomas.

PATIENTS AND METHODS:

Seventy-nine patients with symptomatic cerebral cavernomas underwent RGS radiosurgery at the Bach Mai Hospital, Hanoi, Vietnam. Median dose (single fraction) was 20 Gy (range=14-26 Gy). Endpoints included effect on headache, seizures and tumor size.

RESULTS:

Of 60 patients with headache, 17% had complete response, 82% partial response and 2% stable disease (best response). Of 39 patients with seizures, 31% had complete response, 64% partial response and 5% stable disease. Four patients developed recurrent seizures after 1 year. Regarding the size of cavernoma at 15 months, complete response was observed in 6%, partial response in 75%, stable disease in 15%, progression in 1% and pseudo-progression in 3% of patients. Bleeding within 2 years after RGS radiosurgery occurred in only five patients (6%). RGS dose had no significant impact on outcomes.

CONCLUSION:

RGS radiosurgery provided very high rates of symptom relief in patients with cerebral cavernomas.

KEYWORDS:

Cerebral cavernoma; Rotating-Gamma System; cavernous angioma; cavernous hemangioma; headache; radiosurgery; seizures; symptom relief

PMID:
28668867
DOI:
10.21873/anticanres.11746
[Indexed for MEDLINE]

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