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Biochem Biophys Res Commun. 2017 Aug 26;490(3):1080-1085. doi: 10.1016/j.bbrc.2017.06.170. Epub 2017 Jun 28.

Omega-3 fatty acids promote fatty acid utilization and production of pro-resolving lipid mediators in alternatively activated adipose tissue macrophages.

Author information

1
Department of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, Czech Republic; Charles University in Prague, Faculty of Science, Department of Analytical Chemistry, Albertov 2030, 128 43 Prague, Czech Republic.
2
Department of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, Czech Republic.
3
Department of Adipose Tissue Biology, Institute of Physiology of the Czech Academy of Sciences, Videnska 1083, 14220 Praha 4, Czech Republic. Electronic address: ondrej.kuda@fgu.cas.cz.

Abstract

It is becoming increasingly apparent that mutual interactions between adipocytes and immune cells are key to the integrated control of adipose tissue inflammation and lipid metabolism in obesity, but little is known about the non-inflammatory functions of adipose tissue macrophages (ATMs) and how they might be impacted by neighboring adipocytes. In the current study we used metabolipidomic analysis to examine the adaptations to lipid overload of M1 or M2 polarized macrophages co-incubated with adipocytes and explored potential benefits of omega-3 polyunsaturated fatty acids (PUFA). Macrophages adjust their metabolism to process excess lipids and M2 macrophages in turn modulate lipolysis and fatty acids (FA) re-esterification of adipocytes. While M1 macrophages tend to store surplus FA as triacylglycerols and cholesteryl esters in lipid droplets, M2 macrophages channel FA toward re-esterification and β-oxidation. Dietary omega-3 PUFA enhance β-oxidation in both M1 and M2. Our data document that ATMs contribute to lipid trafficking in adipose tissue and that omega-3 PUFA could modulate FA metabolism of ATMs.

KEYWORDS:

Adipose tissue macrophages; Fatty acid re-esterification; Lipid mediators; Lipolysis; Omega-3 PUFA

PMID:
28668396
DOI:
10.1016/j.bbrc.2017.06.170
[Indexed for MEDLINE]

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