Format

Send to

Choose Destination
Dig Liver Dis. 2017 Aug;49(8):924-928. doi: 10.1016/j.dld.2017.05.017. Epub 2017 May 30.

Molecular analysis of sentinel lymph node in colon carcinomas by one-step nucleic acid amplification (OSNA) reduces time to adjuvant chemotherapy interval.

Author information

1
Digestive and Surgical Oncology Department, Lariboisière Hospital, Assistance publique-Hôpitaux de Paris, 2 rue Ambroise-Paré, 75010, Paris, France.
2
Department of Pathology, Lariboisière Hospital, Assistance publique-Hôpitaux de Paris, 2 rue Ambroise-Paré, 75010, Paris, France.
3
Department of Medical Oncology, Saint-Antoine Hospital, Assistance publique-Hôpitaux de Paris, 184, rue du Faubourg-Saint-Antoine, 75012 Paris, France; University Pierre et Marie Curie (UMPC), Paris VI,4 Place Jussieu, Paris 75005, France.
4
Digestive and Surgical Oncology Department, Lariboisière Hospital, Assistance publique-Hôpitaux de Paris, 2 rue Ambroise-Paré, 75010, Paris, France; Paris Diderot University, USPC, Sorbonne Paris Cité, CART, INSERM U965, CART Carcinomatosis Angiogenesis and Translational Research F-74575 Paris, France.
5
Digestive and Surgical Oncology Department, Lariboisière Hospital, Assistance publique-Hôpitaux de Paris, 2 rue Ambroise-Paré, 75010, Paris, France; Paris Diderot University, USPC, Sorbonne Paris Cité, CART, INSERM U965, CART Carcinomatosis Angiogenesis and Translational Research F-74575 Paris, France. Electronic address: marc.pocard@gmail.com.

Abstract

BACKGROUND:

The interval between surgery and adjuvant chemotherapy (AC) is a predictive factor of survival in high-risk colon cancer (CC). This study aimed to evaluate the impact of intraoperative sentinel lymph node (SLN) analysis using the one-step nucleic acid amplification (OSNA) technique on the time interval between surgery and AC.

METHODS:

We performed a prospective study analyzing 56 consecutive patients who had surgery for CC between July 2012 and October 2014, including 20 patients needing AC. SLN status was determined intraoperatively in 17 patients in the OSNA group; when positive, a portacath (PAC) was placed during the procedure for upcoming AC. In the remaining patients, we proceeded without SLN status determination and the PAC was installed after definitive histopathological analysis of the specimen if needed.

RESULTS:

There was no difference between the groups regarding cancer staging, duration of hospitalization (7.5days in the OSNA group and 10days in the control group, p=0.43) and major complications (20% vs 30% respectively, p=0.55). The time interval between surgery and adjuvant chemotherapy was significantly shorter in the OSNA group at 35 (±8) days vs 67 (±36) days (p=0.021).

CONCLUSION:

SLN status determination by the OSNA technique is safe, feasible and could significantly reduce time between surgery and adjuvant chemotherapy in a pilot study.

KEYWORDS:

Adjuvant chemotherapy; Colon cancer; OSNA; Sentinel lymph node

PMID:
28668271
DOI:
10.1016/j.dld.2017.05.017
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center