Format

Send to

Choose Destination
Eur J Epidemiol. 2017 Jul;32(7):559-566. doi: 10.1007/s10654-017-0280-9. Epub 2017 Jun 30.

The association between leisure-time physical activity, low HDL-cholesterol and mortality in a pooled analysis of nine population-based cohorts.

Author information

1
School of Sport, Exercise and Health Sciences, National Centre for Sport & Exercise Medicine-East Midlands, Loughborough University, Loughborough, LE11 3TU, UK. G.ODonovan@lboro.ac.uk.
2
School of Sport, Exercise and Health Sciences, National Centre for Sport & Exercise Medicine-East Midlands, Loughborough University, Loughborough, LE11 3TU, UK.
3
Department of Epidemiology and Public Health, University College London, London, WC1E 6BT, UK.
4
Charles Perkins Centre, Prevention Research Collaboration, School of Public Health, University of Sydney, Sydney, Australia.

Abstract

The objective of this study was to investigate associations between leisure-time physical activity, low high-density lipoprotein cholesterol (HDL-C) and mortality. Self-reported leisure-time physical activity, HDL-C concentration, and mortality were assessed in 37,059 adults in Health Survey for England and Scottish Health Survey. Meeting physical activity guidelines was defined as ≥150 min wk-1 of moderate-intensity activity, ≥75 min wk-1 of vigorous-intensity activity, or equivalent combinations. Low HDL-C was defined as <1.03 mmol L-1. Cox proportional hazard models were adjusted for age, sex, smoking, total cholesterol, systolic blood pressure, body mass index, longstanding illness, and socioeconomic status. There were 2250 deaths during 326,016 person-years of follow-up. Compared with those who met physical activity guidelines and whose HDL-C was normal (reference group), all-cause mortality risk was not elevated in those who met physical activity guidelines and whose HDL-C concentration was low (hazard ratio: 1.07; 95% confidence interval: 0.75, 1.53). Compared with the reference group, all-cause mortality risk was elevated in those who did not meet physical activity guidelines and whose HDL-C was normal (1.37; 1.16, 1.61), and in those who did not meet physical activity guidelines and whose HDL-C was low (1.65; 1.37, 1.98). Cardiovascular disease mortality hazard ratios were similar, although confidence intervals were wider. There was no statistically significant evidence of biological interaction between physical inactivity and low HDL-C. This novel study supports the notion that leisure-time physical activity be recommended in those with low HDL-C concentration who may be resistant to the HDL-raising effect of exercise training.

KEYWORDS:

Biological interaction; Cholesterol; Mortality; Physical activity

PMID:
28667447
PMCID:
PMC5570782
DOI:
10.1007/s10654-017-0280-9
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center