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J Biol Chem. 2017 Jun 30;292(26):11136-11137. doi: 10.1074/jbc.H117.787614.

A time for promiscuity in a eukaryotic recombinase.

Author information

1
From the Department of Biochemistry, Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242 maria-spies@uiowa.edu.

Abstract

The exchange of DNA strands between broken and intact molecules lies at the heart of fundamental cellular processes ranging from repairing DNA damage by homologous recombination to generation of genetic diversity during sexual reproduction. New work by Lee and colleagues utilizes the DNA curtain method, an elegant single-molecule technique, to demonstrate common and idiosyncratic features in the DNA strand exchange mechanisms of three RecA-family recombinases, bacterial RecA, and eukaryotic Rad51 and Dmc1 proteins.

PMID:
28667173
PMCID:
PMC5491794
DOI:
10.1074/jbc.H117.787614
[Indexed for MEDLINE]
Free PMC Article

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