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Ann Clin Lab Sci. 2017 May;47(3):354-356.

Mitochondrial Iron Accumulation in Parietal and Chief Cells in Iron Pill Gastritis Following Billroth II Gastrectomy: Case Report Including Electron Microscopic Examination.

Author information

1
Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
2
Department of Gastroenterology, New York Harbor Health Care System, Brooklyn, NY, USA.
3
Department of Gastroenterology, SUNY Downstate Medical Center, Brooklyn, NY, USA.
4
Pathology and Laboratory Medicine Service, New York Harbor Health Care System, Brooklyn, NY, USA.
5
Department of Pathology, SUNY Downstate Medical Center, Brooklyn, NY, USA mrpincus2010@gmail.com matthew.pincus@downstate.edu rosemary.wieczorek@va.gov.

Abstract

Iron pill gastritis has been shown to be associated with superficial gastric erosion and deposition of iron in lamina propria and gastric antral glands. However, iron absorption in gastric parietal and chief cells is rare. We present a case of a 62-year-old man with iron deficiency anemia. His past medical history is significant for Billroth II surgery. His medications include ferrous sulphate 325mg. Esophagogastroduodenoscopy showed diffuse circumferential abnormal mucosa at the gastro-jejunal anastomosis. The mucosa was erythematous and violaceous. Biopsy showed reactive gastropathy with iron deposits predominantly in macrophages, parietal cells, and chief cells. These findings were confirmed by iron stain and later by electron micrography of the gastric mucosa that showed iron deposits in mitochondria and cytoplasm of the parietal and chief cells.

KEYWORDS:

Iron-induced gastritis; gastric siderosis; parietal and chief cells

PMID:
28667040
[Indexed for MEDLINE]

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