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Pharmacol Biochem Behav. 2017 Nov;162:55-61. doi: 10.1016/j.pbb.2017.06.013. Epub 2017 Jun 28.

Circadian neurons in the lateral habenula: Clocking motivated behaviors.

Author information

1
Institute of Cellular and Integrative Neuroscience, CNRS-UPR 3212 Strasbourg France, 5 rue Blaise Pascal, 67084 cedex Strasbourg, France. Electronic address: jmendoza@inci-cnrs.unistra.fr.

Abstract

The main circadian clock in mammals is located in the hypothalamic suprachiasmatic nucleus (SCN), however, central timing mechanisms are also present in other brain structures beyond the SCN. The lateral habenula (LHb), known for its important role in the regulation of the monoaminergic system, contains such a circadian clock whose molecular and cellular mechanisms as well as functional role are not well known. However, since monoaminergic systems show circadian activity, it is possible that the LHb-clock's role is to modulate the rhythmic activity of the dopamine, serotonin and norephinephrine systems, and associated behaviors. Moreover, the LHb is involved in different pathological states such as depression, addiction and schizophrenia, states in which sleep and circadian alterations have been reported. Thus, perturbations of circadian activity in the LHb might, in part, be a cause of these rhythmic alterations in psychiatric ailments. In this review the current state of the LHb clock and its possible implications in the control of monoaminergic systems rhythms, motivated behaviors (e.g., feeding, drug intake) and depression (with circadian disruptions and altered motivation) will be discussed.

KEYWORDS:

Circadian; Clock genes; Depression; Feeding; Lateral habenula; Motivation

PMID:
28666896
DOI:
10.1016/j.pbb.2017.06.013
[Indexed for MEDLINE]

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