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Acta Psychiatr Scand. 1985 Sep;72(3):315-7.

Valproate as psychotropic agent. Interactions and adverse cerebral reactions.

Abstract

Recent data stress the psychotropic actions of valproate in schizo-affective disorder. Four patients are reported presenting an altered state of consciousness and prominent EEG dysfunction following combined valproate/neuroleptic drug treatment. Similar cerebral reactions have been reported in anti-epileptic poly- and monotherapy, and the pathogenetic considerations are discussed. Further investigations of the interactions of valproate with other psychotropic agents are highly mandatory.

PMID:
2866665
[Indexed for MEDLINE]
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