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Am J Emerg Med. 2018 Jan;36(1):5-11. doi: 10.1016/j.ajem.2017.06.039. Epub 2017 Jun 22.

Diagnostic performance of initial serum albumin level for predicting in-hospital mortality among aspiration pneumonia patients.

Author information

1
Department of Emergency Medicine, Research Institute of Clinical Medicine of Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju-si, Republic of Korea.
2
Department of Emergency Medicine, Research Institute of Clinical Medicine of Chonbuk National University and Biomedical Research Institute of Chonbuk National University Hospital, Jeonju-si, Republic of Korea. Electronic address: akynei@naver.com.
3
National Cancer Control Institute, National Cancer Center, Goyang-si, Kyunggi-do, Republic of Korea.

Abstract

PURPOSE:

The predictive value of serum albumin in adult aspiration pneumonia patients remains unknown.

METHODS:

Using data collected during a 3-year retrospective cohort of hospitalized adult patients with aspiration pneumonia, we evaluated the predictive value of serum albumin level at ED presentation for in-hospital mortality.

RESULTS:

248 Patients were enrolled; of these, 51 cases died (20.6%). The mean serum albumin level was 3.4±0.7g/dL and serum albumin levels were significantly lower in the non-survivor group than in the survivor group (3.0±0.6g/dL vs. 3.5±0.6g/dL). In the multivariable logistic regression model, albumin was associated with in-hospital mortality significantly (adjusted odds ratio 0.30, 95% confidential interval (CI) 0.16-0.57). The area under the receiver operating characteristics (AUROC) for in-hospital survival was 0.72 (95% CI 0.64-0.80). The Youden index was 3.2g/dL and corresponding sensitivity, specificity, positive predictive value, negative predictive value, positive and negative likelihood ratio were 68.6%, 66.5%, 34.7%, 89.1%, 2.05 and 0.47, respectively. High sensitivity (98.0%) was shown at albumin level of 4.0g/dL and high specificity (94.9%) was shown at level of 2.5g/dL.

CONCLUSION:

Initial serum albumin levels were independently associated with in-hospital mortality among adult patients hospitalized with aspiration pneumonia and demonstrated fair discriminative performance in the prediction of in-hospital mortality.

KEYWORDS:

Albumin; Aspiration pneumonia; Mortality

PMID:
28666627
DOI:
10.1016/j.ajem.2017.06.039
[Indexed for MEDLINE]

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