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J Infect Dis. 2017 Aug 1;216(3):382-386. doi: 10.1093/infdis/jix297.

Assessment of HIV Screening Tests for Use in Preexposure Prophylaxis Programs.

Author information

1
Virologie.
2
Institut national de la santé et de la recherche médicale (INSERM) Unité mixte de recherche 941, Université de Paris Diderot, Sorbonne Paris Cité.
3
INSERM SC10 US19, Villejuif.
4
Maladies infectieuses, Hôpital Tenon, Assistance Publique Hôpitaux de Paris.
5
Maladies infectieuses, Hôpital de l'Archet, Centre Hospitalier de Nice.
6
Maladies infectieuses, Hôpital G. Dron, Centre Hospitalier Universitaire de Tourcoing.
7
Maladies infectieuses, Centre Hospitalier Universitaire de Nantes.
8
Maladies infectieuses, Centre Hospitalier de l'Université de Montréal, Canada.
9
Maladies infectieuses, Hôpital de la Croix Rousse, Centre Hospitalier et Universitaire de Lyon , France.
10
Centre national de référence du VIH Primo-infection.
11
Université Paris-Sud, Université Paris-Saclay, Paris.
12
Maladies infectieuses, Hôpital Saint-Louis.

Abstract

Preexposure prophylaxis programs involve frequent human immunodeficiency virus (HIV) testing. We evaluated the sensitivity of 2 antigen/antibody immunoassays (Architect and Bioplex), 2 antibody-based rapid tests (Vikia-HIV-1/2 and Autotest-VIH), and 1 antigen/antibody rapid test (Alere HIV Combo) for the diagnosis of HIV infection. Among the 31 HIV-1-infected participants in the ANRS-IPERGAY trial, HIV-1 RNA was detected alone in only 2. The sensitivities of the Architect and Bioplex assays were 83% (95% confidence interval [CI], 76%-99%) and 82% (95% CI, 63%-94%), respectively. The sensitivities of the Vikia, Autotest, and Alere tests were 54% (95% CI, 34%-72%), 50% (95% CI, 31%-69%), and 78% (95% CI, 58%-91%), respectively. Antigen/antibody tests should be preferred to avoid missing cases of acute HIV infection and to decrease the related risks of viral transmission and emergence of drug resistance.

KEYWORDS:

HIV diagnosis; HIV-1; HIV-1 RNA; PrEP; acute infection; antigen/antibody test; rapid test; recent infection

PMID:
28666370
DOI:
10.1093/infdis/jix297
[Indexed for MEDLINE]

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