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Cell. 2017 Jun 29;170(1):158-171.e8. doi: 10.1016/j.cell.2017.06.018.

Complement-Related Regulates Autophagy in Neighboring Cells.

Author information

1
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA; Department of Embryology, Carnegie Institution for Science, 3520 San Martin Dr., Baltimore, MD 21218, USA.
2
School of Cellular and Molecular Medicine, Faculty of Biomedical Sciences, University of Bristol, University Walk, Bristol BS8 1TD, UK.
3
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA.
4
Department of Chemistry and Molecular Biophysics & Biochemistry, Yale University, New Haven, CT 06520, USA.
5
Junger's Center for Neurosciences Research, Department of Neurology, Oregon Health and Science University, 3181 SW Sam Jackson Park Road, Portland, OR 97239, USA.
6
Department of Molecular, Cell and Cancer Biology, University of Massachusetts Medical School, Worcester, MA 01605, USA. Electronic address: eric.baehrecke@umassmed.edu.

Abstract

Autophagy degrades cytoplasmic components and is important for development and human health. Although autophagy is known to be influenced by systemic intercellular signals, the proteins that control autophagy are largely thought to function within individual cells. Here, we report that Drosophila macroglobulin complement-related (Mcr), a complement ortholog, plays an essential role during developmental cell death and inflammation by influencing autophagy in neighboring cells. This function of Mcr involves the immune receptor Draper, suggesting a relationship between autophagy and the control of inflammation. Interestingly, Mcr function in epithelial cells is required for macrophage autophagy and migration to epithelial wounds, a Draper-dependent process. This study reveals, unexpectedly, that complement-related from one cell regulates autophagy in neighboring cells via an ancient immune signaling program.

KEYWORDS:

autophagy; complement; immune-receptor signaling; programmed cell death

PMID:
28666117
PMCID:
PMC5533186
DOI:
10.1016/j.cell.2017.06.018
[Indexed for MEDLINE]
Free PMC Article

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