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Biomaterials. 2017 Oct;141:29-39. doi: 10.1016/j.biomaterials.2017.05.040. Epub 2017 May 24.

Augmented glioma-targeted theranostics using multifunctional polymer-coated carbon nanodots.

Author information

1
Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China.
2
Department of Neurosurgery, Affiliated Hospital of Nantong University, Nantong 226001, China.
3
Pharmaceutical Biotechnology, Center for System-based Drug Research, Center for Nanoscience (CeNS), Ludwig-Maximilians-Universität München, Munich 81377, Germany.
4
Center for Advanced Low-dimension Materials, Donghua University, Shanghai 201620, China; Center of Analysis and Measurement, Fudan University, Shanghai 200433, China. Electronic address: ywang@dhu.edu.cn.
5
Department of Pharmaceutics, School of Pharmacy, Key Laboratory of Smart Drug Delivery, Ministry of Education, Fudan University, Shanghai 201203, China. Electronic address: rqhuang@fudan.edu.cn.

Abstract

Overcoming biological barriers to imaging-guided site-specific delivery of therapeutics is the goal of current nanomedicine designs. Here, multifunctional polymer-coated carbon nanodots with an interleukin-6 (IL-6) fragment peptide for receptor-targeting (pCDPI) were prepared for drug delivery. The pCDPI exhibits small hydrodynamic diameters, high water solubility and biocompatibility. In vitro and in vivo results demonstrated that pCDPI can overcome the blood-brain barrier (BBB) and deeply penetrate into orthotopic glioma in mice, to inhibit IL-6-induced cell proliferation and achieve imaging-guided targeted drug delivery. Simultaneously, a pH-sensitive sustained release of doxorubicin (DOX) accompanied with real-time fluorescence monitoring was realized. A distinct synergistic therapeutic outcome could be achieved which suggests the presented nanomedicine having promising potential for future cancer treatments.

KEYWORDS:

Blood-brain barrier; Interleukin-6 receptor; Polymer-coated carbon nanodots; Real-time monitoring; Theranostics

[Indexed for MEDLINE]

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