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Elife. 2017 Jun 30;6. pii: e25014. doi: 10.7554/eLife.25014.

Meru couples planar cell polarity with apical-basal polarity during asymmetric cell division.

Author information

1
Apoptosis and Proliferation Control Laboratory, The Francis Crick Institute, London, United Kingdom.
2
Department of Biology, Institute of Molecular Systems Biology, ETH Zürich, Zürich, Switzerland.
3
Competence Center Personalized Medicine UZH/ETH, Zürich, Switzerland.

Abstract

Polarity is a shared feature of most cells. In epithelia, apical-basal polarity often coexists, and sometimes intersects with planar cell polarity (PCP), which orients cells in the epithelial plane. From a limited set of core building blocks (e.g. the Par complexes for apical-basal polarity and the Frizzled/Dishevelled complex for PCP), a diverse array of polarized cells and tissues are generated. This suggests the existence of little-studied tissue-specific factors that rewire the core polarity modules to the appropriate conformation. In Drosophila sensory organ precursors (SOPs), the core PCP components initiate the planar polarization of apical-basal determinants, ensuring asymmetric division into daughter cells of different fates. We show that Meru, a RASSF9/RASSF10 homologue, is expressed specifically in SOPs, recruited to the posterior cortex by Frizzled/Dishevelled, and in turn polarizes the apical-basal polarity factor Bazooka (Par3). Thus, Meru belongs to a class of proteins that act cell/tissue-specifically to remodel the core polarity machinery.

KEYWORDS:

Bazooka/Par3; D. melanogaster; RASSF9/RASSF10; apical-basal polarity; asymmetric cell division; developmental biology; planar cell polarity; sensory organ precursor; stem cells

PMID:
28665270
PMCID:
PMC5493435
DOI:
10.7554/eLife.25014
[Indexed for MEDLINE]
Free PMC Article

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